The issue of natural disasters and their impact on the population of Bukovina may represent a field of research for biologists and historians, demographers and sociologists. The nineteenth century was less auspicious in the history of the province that has experienced many harmful effects of destructive factors: from hostile weather conditions, to famine and epidemics. Population of Bukovina was not spared by the great waves of epidemics, and the quarantine measures were more or less effective in preventing the spread of diseases. A large number of people, mostly adults, fell victim to cholera. The aim of the article is to illustrate the impact of the epidemic - known as the "Humdinger plague" - on demographic and socio-cultural evolution of the province.