Antiviral activity of porphyrins №1 and №3, and their metal complexes №2 and №4 on model systems becteriophage-bacteria and virus-culture of plant tissues was studied. Dependence between the level of infection inhibition, substance concentration and presence of coordinate metal atom was determined. Aggregation of viral particles under the influence of porphyrins was shown. The effect of porphyrins on the extracted nucleic acid of virus was observed.