The complex antiviral preparations including YM , diacetil-DGT, DGT, cyanoguanidine, alkan-sulfatic acids and second metabolites of microorganisms have been studied and appeared to be effective as for potato plants recovering in vitro of the Х-virus, sofor protection of recovered and healthy plants in the field conditions and in covered soil. It has been shown that complex preparations essentially inhibited the distribution of the tobacco mosaic virus and tomato spotted wilt virus in the field conditions and their reproduction in the plant tissues in vitro and in vivo. The surfactant substances of microbial origin used in the complex preparations, had remarkable benefits due to their lower toxicity over synthetic ones and give new facilities in elaboration of antiviral active compositions for the practical usage.